Climate change impacts social-ecological systems in mountainous areas by increasing certain natural disasters and changing nature’s contributions to people (NCP). Nature-based solutions (NbS) are increasingly implemented to help local communities adapt to climatic hazards. However, the relevance of their location in relation to those hazards and local NCP has hardly been addressed. In the PORTAL (Pathways of Transformation in the Alps) project, we identified and mapped a portfolio of 97 NbS for climate change adaptation in the European Alps. Most NbS addressed drought or soil instability and aimed to provide multiple NCP simultaneously such as wood production and protective function against landslides. We analysed whether NbS are located where they are the most needed, according to both current and future intensity of the hazards they aim to address and to supply-flow-demand indicators of the NCP they aim to provide. We found that the location of NbS is not overall related to current supply-flow-demand indicators of most NCP, nor to the intensity of hazards. Nevertheless, NbS addressing droughts and floods are located in areas where these hazards are more intense, but do not match higher values for NCP indicators. Conversely, NbS aiming to produce wood and to provide protective function against landslides are located in areas with greater levels of these NCP, regardless of the intensity of hazards. These results suggest that hazards and NCP indicators are not the main drivers of NbS implementation. We argue that integrating local climate conditions and current NCP flows is needed to underpin a macro-regional strategy for planning NbS implementation.